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Raccoon polyomavirus: example or exception of polyomavirus driven oncogenesis?
Schreiberová, Lucie ; Španielová, Hana (advisor) ; Hirsch, Ivan (referee)
Polyomaviruses (PyV) are widespread through human and animal populations and typically associated with asymptomatic persistent infection. Rarely, natural PyV infections can lead to oncogenic transformation. Virus genome is usually integrated into the host DNA of tumour tissue. Over the past few years, an increased number of very aggressive brain tumours and olfactory tumours have been observed in raccoons. These tumours are associated with the newly discovered raccoon polyomavirus, which was found as an intact episome in host cells. This bachelor thesis is therefore focused on comparison of current state of knowledge on raccoon polyomavirus with previously described mechanisms of PyV tumorogenesis. Unlike for other PyVs, the fact that primary neuronal stem cell infection is most likely to occur can play a key role in raccoon polyomavirus driven oncogenesis. Tumours also exhibit unusually high expression of virus-encoded micro RNA that can be connected with tumour induction. Similary to other tumours caused by PyV, a large amount of early viral proteins with oncogenic potential is found in tumours. Revealing unknown factors responsible for the development of tumours caused by raccoon polyomavirus may help in understanding of mechanisms of oncogenesis. Key words Polyomavirus, oncogenesis, raccoon...
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